2006 Mercedes-benz E350 reliability record
NHTSA consumer complaints and recall campaigns for the 2006 Mercedes-benz E350 from the dataset labeled 2026. The source file does not provide an exact snapshot date. Use the reported issues to guide further checks; these counts do not establish failure rates or repair costs.
- NHTSA complaints
- 482
- Dataset year: 2026; snapshot day not provided
- Top problem area
- FUEL/PROPULSION SYSTEM
- 144 complaints
- Recalls on record
- 4
- see below
- Reported harm
- 20 reported crashes · 36 injuries · 3 deaths · 13 fires
How this record compares
raw NHTSA counts, not defect ratesCounts are not adjusted for vehicles sold, time in service or reporting frequency. A larger count does not establish a higher chance of failure, and these comparisons do not set the maintenance budget in our calculator.
Complaint rank
#1,084
of 4,194 vehicle records
Vs Mercedes-benz median
+313
median 169 across 69 Mercedes-benz records
Vs 2004-2008
+207
median 275 complaints in 883 records
Top component share
30%
Fuel/Propulsion System: 144 complaints
What owners report fails — 2006 Mercedes-benz E350
- FUEL/PROPULSION SYSTEM 144
- FUEL SYSTEM, GASOLINE 75
- ENGINE 50
- SERVICE BRAKES 46
- POWER TRAIN 29
4 recalls on record for the 2006 Mercedes-benz E350
- NHTSA 24V874000 · 2025 · VISIBILITY:SUN/MOON ROOF ASSEMBLY A detached sunroof panel can become a road hazard, increasing the risk of a crash.
- NHTSA 22V954000 · 2023 · VISIBILITY:SUN/MOON ROOF ASSEMBLY A detached sunroof panel may become a road hazard, increasing the risk of a crash.
- NHTSA 21V196000 · 2021 · VISIBILITY:SUN/MOON ROOF ASSEMBLY A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash.
- NHTSA 19V918000 · 2020 · VISIBILITY:SUN/MOON ROOF ASSEMBLY A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash.
Estimate the 5-year cost to own a 2006 Mercedes-benz E350
Build a separate budget with your purchase price, insurance quote, mileage and maintenance estimate. Complaint counts do not enter that calculation. Unknown local taxes and fees stay listed as costs to confirm.
Open TCO calculatorThese are unverified consumer reports and manufacturer recalls filed with the National Highway Traffic Safety Administration — not validated defect rates, and not adjusted for how many 2006 Mercedes-benz E350 units were produced or sold. High-volume and older vehicles naturally accumulate more complaints. Use this as one research signal, not a verdict on any individual vehicle. Dataset year: 2026; exact snapshot day not supplied. Source: NHTSA Office of Defects Investigation (public domain).
Frequently asked questions
Is the 2006 Mercedes-benz E350 reliable?
NHTSA has 482 consumer complaints on record for the 2006 Mercedes-benz E350 and 4 recalls. The most-reported problem area is fuel/propulsion system (144 reports). These are unverified consumer reports filed with the government, not validated failure rates, and are not adjusted for how many 2006 Mercedes-benz E350 units were produced — popular vehicles naturally accumulate more reports.
What are the most common problems with the 2006 Mercedes-benz E350?
Owners most often report problems with: fuel/propulsion system (144), fuel system, gasoline (75), engine (50), service brakes (46). Each figure is the number of complaints filed with NHTSA for this exact model year.
How much does it cost to own a 2006 Mercedes-benz E350?
This complaint dataset does not measure repair prices or predict a maintenance budget for the 2006 Mercedes-benz E350. Use your purchase price, insurance quotes, fuel use and a maintenance estimate in the separate five-year cost calculator. It does not convert complaint counts into repair costs, and any unknown taxes remain excluded and clearly listed.